Indole-3-carbinol, derived from Cruciferous vegetables is an estrogen receptor antagonist considered a preventive agent that is naturally present in diet.
Does indole fight estrogen?
Indole-3-carbinol (I3C), a compound occurring naturally in cruciferous vegetables, exhibits a potent antitumor activity via its regulation of estrogen activity and metabolism.
Does indole-3-carbinol lower estrogen?
I3C decreases estrogen-driven luciferase activity. Treatment with genistein results in an even greater decrease. Treatment with the two phytochemicals reduces expression significantly more than would have been predicted if the effect of the two phytochemicals were additive, which indicates a clearly synergistic effect.
What are indoles in food?
What are Indoles? Indoles are a type of phytochemical which are mainly associated with prevention of cancer. Found in cruciferous vegetables, it acts as a strong antioxidant and protects the lining of body cells. Indole-3-carbinol is the form found in these vegetables.
What are the benefits of indole-3-carbinol?
Indole-3-carbinol, also called I3C, is a resulting compound that comes from eating vegetables such as Brussels sprouts, cabbage, cauliflower, broccoli, and kale. It is known to stimulate detoxifying enzymes in the gut and liver.
Does I3C increase testosterone?
According to our results, several steroid hormones (estradiol, estrone sulphate and androstenedione) were significantly increased in I3C treated tumor homogenates while testosterone was diminished. Interestingly, testosterone was significantly increased in the sera of I3C treated mice.
Does indole-3-carbinol have side effects?
Possible Side Effects
There isn’t much research specific to humans, but lab studies have shown that I3C may interact with certain drugs such as cytochrome P450 1A2 substrate drugs.
Does indole-3-carbinol really work?
There is some evidence that long-term use of indole-3-carbinol might reduce tumor (papilloma) growth in patients with recurrent respiratory papillomatosis. Laryngeal papillomatosis. Prevention of breast cancer.
Does dim increase estrogen levels?
Improved estrogen metabolism with DIM produces more good estrogen metabolites, which compete with testosterone for protein binding, helping to maintain a slightly higher free testosterone level. In men, too much estrogen builds up in three common situations: obesity, excessive alcohol use, and smoking.
Does indole-3-carbinol make you gain weight?
I3C supplementation significantly ameliorated HFD-induced increases in body weight gain, visceral fat pad weights and plasma lipid levels.
Does jasmine smell like poop?
Indoles are a chemical compound that can either smell like jasmine (jasmine is naturally indolic) or like feces. They can also be created synthetically, so perfumers use them to intensify a floral fragrance.
What does indole mean?
: a crystalline alkaloid compound C8H7N that is a decomposition product of proteins containing tryptophan, that can be made synthetically, and that is used in perfumes also : a derivative of indole.
What are indole levels?
Listen to pronunciation. (IN-dole) A type of chemical found in plants and in certain vegetables, such as broccoli, cabbage, and cauliflower. Indoles may promote good health and are being studied in the prevention of certain types of cancer, including breast cancer, prostate cancer, and colon cancer.
How long does it take for I3C to work?
Both supplements take about one month to work, but they are definintely worth the wait.
Is dim or indole-3-carbinol better?
In summary, we have known for a long time that I3C is partially responsible for many of the beneficial effects of consuming cruciferous vegetables. I3C breaks down to many different active metabolites, but DIM appears to be the most stable, and the most measurable, making it easier to isolate.
What is Meta I 3 C used for?
Meta I-3-C is a unique, highly stabilized formula designed to promote healthy estrogen metabolism and activity with indole-3-carbinol (I3C), which provides a full spectrum of beneficial metabolites— including diindolylmethane (DIM). Benefits: Helps support the health of estrogen-sensitive tissues.